import requests

url = "https://{FUSION HOST}/api/index-profiles"

payload = {
    "id": "SiteSearch",
    "indexPipeline": "newSiteSearchProfile",
    "collection": "SiteSearch",
    "parser": "SiteSearch"
}
headers = {
    "Authorization": "Basic <encoded-value>",
    "Content-Type": "application/json"
}

response = requests.post(url, json=payload, headers=headers)

print(response.text)

{
  "id": "default",
  "indexPipeline": "<string>",
  "collection": "<string>",
  "parser": "<string>"
}